How citrullination invaded rheumatoid arthritis research
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چکیده
منابع مشابه
How citrullination invaded rheumatoid arthritis research
Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. In the first years after the initial publications, the focus was on the antibodies directed to citrullinated proteins. It is now realized that citrullinating enzymes and citrullinated prot...
متن کاملRheumatoid arthritis and periodontitis; a possible link via citrullination.
Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in l...
متن کاملMyocardial citrullination in rheumatoid arthritis: a correlative histopathologic study
INTRODUCTION The aim of this study was to explore the presence and localization of myocardial citrullination in samples from rheumatoid arthritis (RA) patients compared to rheumatic and non-rheumatic disease control groups. METHODS Archived myocardial samples obtained during autopsy from 1995 to 2009 were assembled into four groups: RA; scleroderma; fatal myocarditis; and non-rheumatic diseas...
متن کاملLocal administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
INTRODUCTION Protein citrullination is present in the rheumatoid synovium, presumably contributing to the perpetuation of chronic inflammation, in the presence of specific autoimmunity. As a result, the present study examined the possibility that effective antirheumatic treatment will decrease the level of synovial citrullination. METHODS Synovial biopsies were obtained from 11 rheumatoid art...
متن کاملCitrullination in extra-articular manifestations of rheumatoid arthritis.
BACKGROUND Anti-citrullinated protein antibodies have been detected with high specificity in serum of patients with rheumatoid arthritis (RA), and citrullination of proteins may play a key role in the pathogenesis of RA. We therefore investigated the presence of citrullination in two extra-articular manifestations of RA, interstitial pneumonia (IP) and rheumatoid nodules. METHODS Open-lung bi...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2014
ISSN: 1478-6354
DOI: 10.1186/ar4458